The ames test

Ames, the Ames test, and the causes of cancer.

Mutagenicity of glutathione and cysteine in the Ames test.

Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term...

Antimutagenic Activity of Olive Leaf Aqueous Extract by Ames Test

Medicinal plants are an important source of substances which are claimed to induce anti-inflammatory and antioxidant effects. The leaves of the olive tree (Oleaeur opaea) have been used for medicinal purposes since ancient times and research has suggested that olive leaf extracts have antimicrobial and antimutagenic properties. In this study, Olive leaf aqueous extracts were screened for their ...

Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.

The mutagenicity of ten flavonoids was assayed by the Ames test, in Salmonella typhimurium strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles. The compounds assessed were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In the Ames assay, quer...

Use of Ames test in evaluation of shale oil fractions.

Conditions that affect the sensitivity of the Ames assay of complex hydrocarbon mixtures derived from shale oil were studied. Two fractions, one enriched in polynuclear aromatic compounds (PNA fraction), and a second fraction enriched in aromatic and heterocyclic amines (basic fraction), were selected for most of this work because of their comparatively high mutagenicity (i.e., compared with ra...